RNA folding is the most essential process underlying RNA function
DEAD-box helicase Mss116p is essential for respiratory growth by acting as group I and group II intron splicing factor
Mss116p assists RNA folding
ai5γ group II intron
ai5γ ribozyme D135 achieves its complex architecture by following a direct path, in which formation of the scaffolding domain (D1) constitutes a compact intermediate on the way from the unfolded to the native conformation
A small substructure within D1, the κ–ζ element, was found to control D135 compaction and to initiate a cascade of folding events
Mss116p plays a role in mitochondrial translation and RNA processing
Mss116p influences the folding mechanism in another way: long exon sequences interfere with ai5γ splicing
-------------HDV ribozymes catalyze their own scission from the transcript during rolling circle replication of the hepatitis delta virus
Genomic mapping of these RNAs suggested several biological roles, one of which is the 5' processing of non-LTR retrotransposons
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